Pharmaceuticals, Biotechnology and Life Sciences
Celyad has kicked off the SHRINK trial, a third clinical trial with its lead product candidate CYAD-01 (CAR-T NKG2D), targeting metastatic colorectal patients, the company said Thursday.
Ceylad said on Monday that it’s gotten promising early clinical results at the 3-month follow-up of the first dose-level in the solid tumor arm of the THINK trial (THerapeutic Immunotherapy with CAR-T NKR-2).
The U.S. Patent and Trademark Office (USPTO) has been favorable to Ceylad for the fourth time for production of Allogenic TCR-Deficient CAR-T cells.
Celyad is about to kick the THINK trial in the USA, after the U.S. FDA authorized its initiation. THINK evaluates NKR-2 CAR-T cells in seven indications, five solid cancers and two hematological malignancies.
Celyad has started on Thursday its Therapeutic Immunotherapy with NKR-2 (THINK) trial in Belgium with the first patient giving blood.
To remind, THINK trial is an open-label Phase Ib study to assess the safety and clinical activity of multiple administrations of autologous CAR-T NKR-2 cells in seven refractory cancers.