Stat Inhibitors – Global Pipeline Insight, 2021 Featuring Emerging Drugs Bardoxolone methyl and SHR-0302 – ResearchAndMarkets.com

DUBLIN–(BUSINESS WIRE)–The “Stat Inhibitors – Pipeline Insight, 2021” drug pipelines has been added to ResearchAndMarkets.com’s offering.

This report provides comprehensive insights about 25+ companies and 25+ pipeline drugs in STAT Inhibitors pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Report Highlights

The companies and academics are working to assess challenges and seek opportunities that could influence STAT Inhibitors R&D. The therapies under development are focused on novel approaches to treat/improve STAT Inhibitors.

Emerging Drugs

This segment of the STAT Inhibitors report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Bardoxolone methyl: Reata Pharmaceuticals

Bardoxolone is an investigational, once-daily, orally administered activator of Nrf2, a transcription factor that induces molecular pathways that promote the resolution of inflammation by restoring mitochondrial function, reducing oxidative stress, and inhibiting pro-inflammatory signaling. The FDA has granted Orphan Drug designation to bardoxolone for the treatment of Alport syndrome and autosomal dominant polycystic kidney disease (“ADPKD”). The European Commission has granted Orphan Drug designation in Europe to bardoxolone for the treatment of Alport syndrome. In April 2021, Reata Pharmaceuticals announced that the U.S. Food and Drug Administration (“FDA”) accepted for filing the New Drug Application (“NDA”) for bardoxolone methyl (“bardoxolone”) for the treatment of patients with chronic kidney disease (“CKD”) caused by Alport syndrome.

SHR-0302: Jiangsu Hengrui Medicine Co./ Reistone Biopharma

SHR0302 is a potent and highly selective Janus kinase type 1 (JAK1) inhibitor, STAT3 transcription factor inhibitors and was in-licensed by Reistone from Jiangsu Hengrui Medicine Co., Ltd. Several late stage clinical studies are on-going with both oral and topical dosage forms for several immune-inflammatory diseases including Ulcerative Colitis, Crohn’s disease, etc. The high selectivity of SHR0302 may potentially provide a favorable safety and efficacy profile compared to the pan-JAK inhibitors.

Therapeutics Assessment

This segment of the report provides insights about the different STAT Inhibitors drugs segregated based on following parameters that define the scope of the report, such as:

Major Players

There are approx. 25+ key companies which are developing the therapies for STAT Inhibitors. The companies which have their STAT Inhibitors drug candidates in the most advanced stage, i.e. Pre-registration include, Reata Pharmaceuticals.

Pipeline Activities

The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses STAT Inhibitors therapeutic drugs key players involved in developing key drugs.

Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging STAT Inhibitors drugs.

Key Questions Answered

• How many companies are developing STAT Inhibitors drugs?
• How many STAT Inhibitors drugs are developed by each company?
• How many emerging drugs are in mid-stage, and late-stage of development for the treatment of STAT Inhibitors?
• What are the key collaborations (Industry-Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the STAT Inhibitors therapeutics?
• What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
• What are the clinical studies going on for STAT Inhibitors and their status?
• What are the key designations that have been granted to the emerging drugs?

Key Players

• Bio-Path Holdings
• Jiangsu Hengrui Medicine Co.
• Reata Pharmaceuticals
• Tvardi Therapeutics
• Purple Biotech

Key Products

• BP-1003
• SHR-0302
• Bardoxolone methyl
• TTI-101
• TTI-102
• NT-219

For more information about this drug pipelines report visit https://www.researchandmarkets.com/r/3p8khs

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