Oxurion enrolls patients to test its antibody PlGF in combinationwith Ranibizumab, to treat Diabetic Macular Edema

Oxurion enrolls patients to test its antibody PlGF in combinationwith Ranibizumab, to treat Diabetic Macular Edema

April 4, 2019 Off By Dino Mustafić

Belgian Oxurion has enrolled 70 patients for Phase 2 testing of its THR-317, a humanized antibody against placental growth factor (PlGF), in combination with anti-VEGF (ranibizumab), an anti-vascular endothelial growth factor (VEGF) antibody, for the treatment of Diabetic Macular Edema (DME).

Topline data from the study are expected by Q3 2019, the company said in a press release on Thursday.

The study will test 3 monthly intravitreal injections of THR-317 and ranibizumab in subjects with center-involved DME (CI-DME). The combination of ranibizumab and sham is used as control. Patients will be followed up until 3 months after the last injection.

Patrik De Haes, M.D., CEO of Oxurion nv, said: “We are delighted to announce the earlier than anticipated full enrollment of our Phase 2 study evaluating THR-317 in combination with ranibizumab for the treatment for DME. This proof of concept clinical study will for the first time provide important insights into the additional effect anti-PlGF (THR-317) could provide on top of anti-VEGF therapy, the current standard of care for treating DME patients.