Oxford Biomedica announces update to agreement with Sio Gene Therapies

Oxford Biomedica announces that Sio Gene Therapies intends to cease the license agreement for gene therapy programme in Parkinson’s disease Negligible financial impact on Oxford Biomedica in the short and medium termNon-core, legacy asset to be returned and out-licensed again in due courseOxford Biomedica fully focused as a global vector-agnostic gene and cell therapy innovative CDMO          Oxford, UK – 31 January, 2022: Oxford Biomedica plc (LSE:OXB) (“Oxford Biomedica” or “the Company”), a leading gene and cell therapy group, announced today that it was informed on Monday 31 January by Sio Gene Therapies (Sio) that Sio intends to return the global rights for AXO-Lenti-PD and that they intend to cease work on this gene therapy programme in Parkinson’s Disease. This follows Sio’s announcement today about the resignation of their CEO where Sio also indicates a constraint on resource requirements that has caused Sio to deprioritise the programme. All rights shall be returned to Oxford Biomedica at no cost to the Company. Current status of programmeSio is currently conducting a Phase 2 SUNRISE-PD trial with AXO-Lenti-PD. In October 2020, Sio announced positive six-month follow up data from the second cohort of the trial, showing a 21-point mean improvement in UPDRS Part III ‘OFF’ score, a 40% improvement from baseline based on the two evaluable patients in the study. AXO-Lenti-PD continued to be shown to be well-tolerated with no treatment-related serious adverse events at six months. To date, six patients have been dosed in the Phase 2 study. Oxford Biomedica originally out-licensed AXO-Lenti-PD (previously named OXB-102) to Sio Gene Therapies (previously called Axovant Gene Therapies), in June 2018. Financial guidanceThe Company expects that the impact on revenue will be negligible over at least the coming 24 month period as no financial milestones were expected in the short and medium-term. Next stepsOxford Biomedica does not plan to invest in the development of this non-core legacy asset and plans to out-license it again in due course to a suitable partner with resource capabilities and funding to further develop this asset. Dr. Roch Doliveux, Chair and Interim CEO of Oxford Biomedica, commented: “Following Friday’s announcement, Oxford Biomedica’s goal is to become an innovative global viral vector leader that provides solutions to Cell and Gene Therapy for their process development and manufacturing needs across key viral vectors. The Parkinson’s programme is non-core to our strategy.” Enquiries Oxford Biomedica plc Stuart Paynter, Chief Financial OfficerSophia Bolhassan, Head of Investor RelationsT: +44 (0)1865 783 000 / E: [email protected] Consilium Strategic CommunicationsMary-Jane Elliott / Matthew NealT: +44 (0)7720 088 468 E: [email protected]          About Oxford BiomedicaOxford Biomedica (LSE:OXB) is a leading, fully integrated, gene and cell therapy group. In January 2022, Oxford Biomedica announced that it was broadening its leading viral vector offerings by incorporating Homology Medicines’ established AAV capabilities into a newly formed AAV Manufacturing and Innovation Business in the US with Homology Medicines as a 20% owner. To date, Oxford Biomedica and its subsidiaries (the “Group”) have built a sector leading lentiviral vector delivery platform (LentiVector®), which the Group leverages to develop in vivo and ex vivo products both in-house and with partners. The Group has created a valuable proprietary portfolio of gene and cell therapy product candidates in the areas of oncology, CNS disorders and liver diseases. The Group has also entered into a number of partnerships, including with Novartis, Bristol Myers Squibb, Boehringer Ingelheim, Beam Therapeutics, Arcellx, Cabaletta, Orchard Therapeutics and Santen, through which it has long-term economic interests in other potential gene and cell therapy products. Additionally, the Group has signed a 3-year master supply and development agreement with AstraZeneca for large-scale manufacturing of the adenoviral based COVID-19 vaccine, AZD1222. Oxford Biomedica is based across several locations in Oxfordshire, UK and employs more than 740 people. Further information is available at www.oxb.com.