Novo Nordisk – major shareholder announcement

Bagsværd, Denmark, 21 February 2022 – Novo Nordisk today announced that the company has been notified by BlackRock, Inc. (Blackrock) as follows: Blackrock holds as of 15 February 2022 B shares equal to 4.98% of the entire share capital of Novo Nordisk. The total B shares according to section 38 of the Danish Capital Markets Act, and other financial instruments according to section 39(2)(1) of the Danish Capital Markets Act and financial instruments with similar effects according to section 39(2)(2) of the Danish Capital Markets Act held by Blackrock correspond to 5.00% of the entire share capital and below 5% of the voting rights. Blackrock holds as of 16 February 2022 B shares below 5% of the entire share capital of Novo Nordisk. The total B shares according to section 38 of the Danish Capital Markets Act, and other financial instruments according to section 39(2)(1) of the Danish Capital Markets Act and financial instruments with similar effects according to section 39(2)(2) of the Danish Capital Markets Act held by Blackrock correspond to below 5% of the entire share capital and below 5% of the voting rights. This announcement is in accordance with section 30 of the Danish Capital Markets Act. For a full chain of controlled undertakings through which the voting rights and/or the financial instruments are held, please see the annexes. About Novo NordiskNovo Nordisk is a leading global healthcare company, founded in 1923 and headquartered in Denmark. Our purpose is to drive change to defeat diabetes and other serious chronic diseases such as obesity and rare blood and endocrine disorders. We do so by pioneering scientific breakthroughs, expanding access to our medicines and working to prevent and ultimately cure disease. Novo Nordisk employs about 47,800 people in 80 countries and markets its products in around 170 countries. Novo Nordisk’s B shares are listed on Nasdaq Copenhagen (Novo-B). Its ADRs are listed on the New York Stock Exchange (NVO). Further information Media:   Mette Kruse Danielsen +45 3079 3883 [email protected] Michael Bachner (US)  +1 609 664 7308 [email protected]    Investors:   Daniel Muusmann Bohsen +45 3075 2175 [email protected] Ann Søndermølle Rendbæk +45 3075 2253 [email protected] David Heiberg Landsted +45 3077 6915 [email protected] Jacob Martin Wiborg Rode +45 3075 5956 [email protected] Mark Joseph Root (US) +1 848 213 3219 [email protected]  Company announcement No 16 / 2022 Annex 1: Full chain of controlled undertakings starting with the ultimate controlling natural person or legal entity as of 15 February 2022 Name% of voting rights if it equals or is higher than the notifiable threshold% of voting rights through financial instruments if it equals or is higher than the notifiable thresholdTotal of both if it equals or is higher than the notifiable thresholdBlackRock Japan Co., Ltd.  Below 5%Trident Merger, LLC  Below 5%BlackRock Finance Europe Limited  Below 5%BlackRock Australia Holdco Pty. Ltd.  Below 5%BlackRock Group Limited  Below 5%BlackRock Institutional Trust Company, National Association  Below 5%BlackRock Delaware Holdings Inc.  Below 5%BlackRock Holdco 2, Inc.  Below 5%BlackRock HK Holdco Limited  Below 5%BlackRock (Netherlands) B.V.  Below 5%BlackRock Canada Holdings ULC  Below 5%BlackRock Capital Holdings, Inc.  Below 5%BlackRock Advisors (UK) Limited  Below 5%BlackRock (Singapore) Holdco Pte. Ltd.  Below 5%BlackRock Investment Management Ireland Holdings Limited  Below 5%Amethyst Intermediate, LLC  Below 5% Annex 2: Full chain of controlled undertakings starting with the ultimate controlling natural person or legal entity as of 16 February 2022 Name% of voting rights if it equals or is higher than the notifiable threshold% of voting rights through financial instruments if it equals or is higher than the notifiable thresholdTotal of both if it equals or is higher than the notifiable thresholdBlackRock Japan Co., Ltd.  Below 5%BlackRock Investment Management, LLC  Below 5%BlackRock Investment Management (UK) Limited  Below 5%BlackRock Investment Management (Australia) Limited  Below 5%BlackRock International Limited  Below 5%BlackRock Institutional Trust Company, National Association  Below 5%BlackRock Fund Advisors  Below 5%BlackRock Financial Management, Inc.  Below 5%BlackRock Asset Management North Asia Limited  Below 5%BlackRock Asset Management Deutschland AG  Below 5%BlackRock Asset Management Canada Limited  Below 5%BlackRock Advisors, LLC  Below 5%BlackRock Advisors (UK) Limited  Below 5%BlackRock (Singapore) Limited  Below 5%BlackRock Asset Management Ireland Limited  Below 5%Aperio Holdings, LLC  Below 5%
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PR220221_Major_shareholder_information_Blackrock