New Study Demonstrates Integrin Activation Can Bring the Heat to Cold Melanoma Tumors

HOUSTON, May 18, 2022 (GLOBE NEWSWIRE) — 7 Hills Pharma LLC (“7 Hills” or “7HP”), together with The University of Texas MD Anderson Cancer Center (“MD Anderson”) and Texas Heart Institute (“THI”), released a new study in The Journal of Clinical Investigation, describing the use of 7HP’s novel integrin activator 7HP349 to convert “cold” or non-immunogenic tumor microenvironments to a “hot,” T cell-enriched state, improving the effectiveness of immune checkpoint blockade. The article, entitled “LFA-1 activation enriches tumor-specific CD8+ T cells in a cold tumor model and synergizes with CTLA-4 blockade,” was published by a team at MD Anderson led by Yared Hailemichael, Ph.D., assistant professor of Melanoma Medical Oncology, with co-authors from 7 Hills and THI. 7HP349 is a member of a family of small molecule integrin activators discovered at the Texas Heart Institute in the laboratories of Dr. Peter Vanderslice, Dr. Ronald J. Biediger, and Dr. Darren G. Woodside. The family of compounds was generated using a rational design approach based on their deep understanding of and relationship between the biology and three-dimensional structure of integrins. “This landmark publication is the result of years of forward-looking thinking, innovative chemistry, and keen scientific investigation amongst our multidisciplinary teams and with our interinstitutional partners across the Texas Medical Center,” said Dr. Vanderslice. “Our goal is to bring more effective, less toxic immunotherapy treatments to cancer patients, and we are proud to see our unique approach to immune augmentation validated with this publication.” 7HP partnered with THI in 2014 to commercially develop the technology and soon teamed up with Hailemichael to elucidate the biology underlying these first-in-concept integrin activators. “Our findings shed light on a new approach to improving cancer immunotherapy,” Hailemichael said. “We are excited to help move this therapeutic a step closer to additional clinical studies.” 7HP has garnered both FDA Fast Track and Orphan Drug designations for 7HP349 in advanced melanoma, highlighting the significant unmet needs of these patients. 7HP also recently completed a Phase I clinical trial on 7HP349 demonstrating oral bioavailability and a clean safety profile. “We are grateful for the support of the National Cancer Institute’s SBIR program that has funded this work from pre-clinical validation and IND-enabling studies through completion of Phase I clinical testing,” said Upendra Marathi, CEO of 7HP. “Without their support, both financial and non-financial, our novel approach to reversing resistance to immune checkpoint inhibition could not have been possible.” Hickman, A., Koetsier, J., Kurtanich, T., Nielsen, M. C., Winn, G., Wang, Y., Bentebibel, S.-E., Shi, L., Punt, S., Williams, L., Haymaker, C., Chesson, C. B., Fa’ak, F., Dominguez, A., Jones, R., Kuiatse, I., Caivano, A. R., Khounlo, S., Warier, N. D., Marathi, U., Market, R. V., Biediger, R. J., Craft, J. W., Jr., Hwu, P., Davies, M. A., Woodside, D. G., Vanderslice, P., Diab, A., Overwijk, W. W., Hailemichael, Y. (2022). LFA-1 activation enriches tumor-specific T cells in a cold tumor model and synergizes with CTLA-4 blockade. Journal of Clinical Investigation. https://doi.org/10.1172/jci154152 J Clin Invest. 2022. https://doi.org/10.1172/JCI154152. About 7 Hills Pharma LLC 7 Hills Pharma is a clinical-stage immunotherapy company developing a platform of novel, oral small molecules for the treatment of cancer and prevention of infectious diseases. Our compounds are first-in-concept allosteric integrin activators that leverage a unique mechanism of action to stabilize the cell-cell interactions required to mount an effective immune response. Our lead clinical candidate, 7HP349, is the only reported systemically safe immune stimulant that can activate both cellular and humoral immunity. For more information, visit http://www.7hillspharma.com About 7HP349 7HP349 is 7HP’s lead, clinical-stage integrin agonist. It is a first-in-class, orally delivered small molecule that safely and selectively activates the integrins LFA-1 and VLA-4 to augment the antigen-specific immune response. In preclinical models, 7HP349 has been shown improve the effectiveness of a broad range of immune checkpoint inhibitors and a wide variety of infectious disease vaccines. In a Phase I clinical trial, 7HP349 demonstrated oral bioavailability and clean safety profile at exposures well exceeding therapeutic levels. About Texas Heart Institute The Texas Heart Institute (THI), founded by world-renowned cardiovascular surgeon Dr. Denton A. Cooley in 1962, is a nonprofit organization dedicated to delivering the future of cardiovascular health through exceptional patient care, discovery, and a commitment to learning. THI’s scientists and physicians are spearheading some of the most innovative research in the medical field through its translational basic and clinical research programs in cardiology, cardiovascular surgery, stem cell and gene therapy, and regenerative medicine. As a global leader of patient care for nearly six decades, Texas Heart Institute has been ranked among the top cardiovascular centers in the United States by U.S. News & World Report for the past 30 years. With initiatives ranging from postdoctoral and continued medical education to public outreach and scientific publications, THI is dedicated to spreading awareness and sharing updates on ways to prevent, treat and defeat cardiovascular disease. With over 10 million visitors coming to its website from around the world every year, www.texasheart.org is just one of the ways THI is helping to educate people on the importance of heart health. For more information, please visit https://www.texasheart.org CONTACT: 7 Hills Pharma Media Contact: Rob Bent [email protected]