Acerus’ study shows Natesto significantly increases mean testosterone levels

Acerus Pharmaceuticals said Thursday in a press release that new data showed that Natesto increases serum testosterone and improves symptoms while maintaining normal semen parameters in men with low testosterone through six months.

TORONTO–(BUSINESS WIRE)–Acerus Pharmaceuticals Corporation (TSX:ASP, OTCQB:ASPCF) today announced the presentation of data from the NATESTO^® Spermatogenesis Study as part of the “Late Breaking” Abstract Session at the 75th Annual American Society for Reproductive Medicine (ASRM) Scientific Conference in Philadelphia, PA. Yesterday’s presentation was one of only six abstracts accepted as part of this session.

Findings from the study demonstrated that 95% of men treated with NATESTO^® for hypogonadism for three and six months, maintained their semen parameters within the normal range while increasing serum testosterone levels to normal and improving hypogonadal symptoms. This is the first such study to demonstrate conclusively that a testosterone replacement therapy (TRT) can maintain key fertility parameters in hypogonadal men. Researchers attributed these findings to NATESTO^®’s fast absorption and unique dosing schedule designed to produce fluctuations of testosterone levels in the bloodstream.

“Low testosterone affects about 12% of men under 40, at a time when their interest in having a family may be highest. Unfortunately, the therapies we use to restore testosterone levels can impact sperm production and function, resulting in infertility,” said Ranjith Ramasamy, MD, Associate Professor and Director of Reproductive Urology at the University of Miami School of Medicine and the study’s principal investigator. “Our study shows that NATESTO^® can be a good option for these men. After six months of treatment, the majority of patients in our study were able to maintain normal levels of sperm production and quality. Any patient with a modest decrease in sperm parameters returned to their pre-study sperm levels within three months of stopping treatment, something we don’t often see with other testosterone replacement therapies.”