Multiply Labs and Thermo Fisher Scientific Expand Partnership to Automate Cell Expansion and Separation in Cell Therapy Manufacturing

February 12, 2024 Off By BusinessWire

Automating Thermo Fisher’s cutting-edge, GMP-ready instruments using Multiply Labs’ robotic technology helps reduce costs and accelerates timelines, bringing cell therapy scalability and accessibility within reach

SAN FRANCISCO–(BUSINESS WIRE)–#manufacturing–Through integration with Multiply Labs’ robotic technology, Thermo Fisher Scientific’s advanced, industry-leading cell therapy instruments, including the Thermo Scientific™ Heracell™ VIOS Automated Access CO2 Incubator and the Gibco™ Cell Therapy Systems (CTS™) Rotea™ Counterflow Centrifugation System can now be fully automated for cell therapy manufacturing. This collaboration is an important step forward for cell therapy development and manufacturing with a goal of supporting reduced costs, accelerated production timelines and improved scalability, helping innovative cell therapies reach more patients.

With the automated Heracell VIOS Incubator, up to 18 products can be hosted in parallel when using G-Rex100M bioreactors. This is a steep increase over traditional manual manufacturing, where one or two G-Rex100M bioreactors are used in parallel in a single incubator. The ability to support 18 products at once per incubator signals future scalability, as with two automated incubators, manufacturers would be able to create 36 products at the same time and scale upwards from there as incubators are added.

Furthermore, by automating Thermo Fisher’s CTS Rotea Counterflow Centrifugation System, key manufacturing steps including upstream and downstream cell processing, can be performed automatically. Therefore, automation supports not only increased throughput but also lower labor cost, as these important processes can be executed by a single manufacturing operator. For comparison, traditional manual manufacturing processes typically require 4-8 operators. An end-to-end automated workflow using robotic technology only requires 400-500 sq ft of space compared to the 1000-2000 sq ft of space required for human-operated workflows.

Xavier De Mollerat Du Jeu, Senior Director of Research and Development at Thermo Fisher Scientific, expressed excitement about the expanded partnership, emphasizing its significance in delivering curative therapies to patients more efficiently. “With so many groundbreaking cell therapies available or forthcoming for patients, we cannot afford to let manual processes reduce scalability and stand in the way of access. Not only are we taking our incubator partnership to the next level to deliver a fully-automated GMP product, but together we will engineer the automation of our latest-generation closed system centrifuge – an essential instrument for cell therapy manufacturing,” he added.

Cell therapy innovators and CDMOs can benefit from this collaboration by integrating Thermo Fisher’s top-notch solutions while enjoying the advantages of automation, such as cost reduction and increased throughput. Multiply Labs recently demonstrated that automated and manual cell expansion processes are statistically equivalent. This implies that manufacturers can automate their current cell expansion protocols with minimal alterations and reduced regulatory risk.

Fred Parietti, PhD, Co-Founder and CEO of Multiply Labs, expressed enthusiasm about the collaboration’s potential impact on cell therapy manufacturing. “The goal is to establish a seamlessly automated, plug-and-play process that positively influences patient care. The ongoing partnership with Thermo Fisher plays a crucial role in turning this vision into reality, advancing the realization of cell therapy for the benefit of patients.”

About Multiply Labs

Multiply Labs is a robotics company that provides autonomous manufacturing technology to the pharmaceutical industry. The company develops advanced, cloud-controlled robotic systems that enable the production of individualized drugs at scale. Its customers include some of the largest global organizations in the advanced pharmaceutical manufacturing space. Multiply Labs’ expertise is at the intersection of robotics and biopharma – its team includes mechanical engineers, electrical engineers, computer scientists, software engineers and pharmaceutical scientists. The founding team got in touch because of their shared love of robots at MIT. The company is based in San Francisco, California. For more information, please visit


Thermo Fisher Scientific

Kristin Blake

[email protected]

Multiply Labs

Marae Hartwell

[email protected]