Lyophilization Basics for Pharmaceuticals Webinar: History, Scientific Principles, Cycles and Formulations –

March 17, 2022 Off By BusinessWire

DUBLIN–(BUSINESS WIRE)–The “Lyophilization Basics for Pharmaceuticals: History, Scientific Principles, Cycles and Formulations” webinar has been added to’s offering.

The course will act as an introduction to freeze-drying of pharmaceutical parenteral products. Many drug substances require the extra protection that lyophilization provides, and the formulation of the liquid drug product must be designed to optimize efficacy of the finished dried product.

The course will cover how lyophilization works to convert a liquid drug product into a dried, more-stable powder. Cycle and formulation design will be explained, along with the scientific principles that are at play.

Why Should You Attend

  • To learn the how and why for formulating and designing lyophilization cycles for drugs that will benefit from the freeze-drying process

Learning Objectives

  • Definition of freeze-drying
  • Identify ideal characteristics of a freeze-dried product
  • Determine when freeze-drying is necessary
  • Phases of the LYO cycle, and the scientific principles that drive each phase
  • Formulating drug products for successful freeze-drying
  • Analytical tools used to aid in the formulation and cycle development

Course Agenda:

Section 1: History and background

  • Definition of freeze-drying, history, and commonly freeze-dried materials
  • Desired freeze-dried characteristics
  • Advantages and limitations of freeze-drying
  • Process overview

Section 2: Physical, chemical, and engineering principles

  • Vapor pressure
  • Sublimation and the phase diagram of water
  • The heat of sublimation of ice
  • Rate processes in freeze drying – heat transfer and mass transfer
  • States of matter – crystalline and amorphous

Section 3: LYO cycle phases

  • Freezing (with optional annealing)
  • Primary drying (sublimation of water vapor)
  • Secondary drying (diffusion and evaporation of water that did not freeze as ice)

Section 4: LYO formulations

  • Excipients for small and large molecules

Section 5: Quality product attributes

  • General and specific to freeze-dried products
  • Influence of collapse and eutectic melting

For more information about this webinar visit

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