Idorsia continues to further the science of sleep and insomnia with new daridorexant data and analyses published at Sleep Europe 2024

Allschwil, Switzerland – September 17, 2024 Idorsia Ltd (SIX: IDIA) today announced that new data and analyses of daridorexant, Idorsia’s dual orexin receptor antagonist for the treatment of adults with chronic insomnia, will be presented at Sleep Europe 2024 – the 27th Congress of the European Sleep Research Society (ESRS), taking place in Seville, Spain, September 24–27, 2024. The following posters will be presented: Lederer K, et al. Efficacy and safety of daridorexant in patients with chronic insomnia disorder and comorbid nocturia [P5021], Wednesday, Sep 25, 12:15 – 13:15 and 16:00 – 17:45.McCall WV, et al. Dose-response of daridorexant in insomnia disorder: a meta-analysis of Phase 2 and 3 studies [P298], Wednesday, Sep 25, 12:15 – 13:15 and 16:00 – 17:45.Dauvilliers Y, et al. Effect of daridorexant on wakefulness throughout the night and morning sleepiness in patients with insomnia disorder [P1213], Friday, Sep 27, 10:45 – 13:30.Boof M-L, et al. Repeated dosing of 50 mg daridorexant in patients with severe obstructive sleep apnea: Effect on sleep-disordered breathing and sleep [P1200], Friday, Sep 27, 10:45 – 13:30.Muehlan C, et al. Nighttime Safety of Daridorexant: Response to Noise Stimuli, and effects on Postural Stability, Walking and Memory [P1197], Friday, Sep 27, 10:45 – 13:30.Kaufmann P, et al. Excretion of the Dual Orexin Receptor Antagonist Daridorexant into Breast Milk of Healthy Lactating Women [P1196], Friday, Sep 27, 10:45 – 13:30.Di Marco T, et al. Effect of daridorexant on sleep micro-architecture in adult patients with insomnia disorder – A post-hoc analysis of two pooled Phase 3 studies [P1198], Friday, Sep 27, 10:45 – 13:30.Lettieri CJ, et al. Effect of Daridorexant on Patients with Comorbid Insomnia Disorder and Untreated Mild Obstructive Sleep Apnea: A Post-hoc Analysis of a Phase 3 Study [P1201], Friday, Sep 27, 10:45 – 13:30. The abstracts can be found on the congress website. In addition, Idorsia is supporting a satellite symposium entitled “Overactive wake-signaling and the management of insomnia disorder” on Thursday, September 26, from 12:15-13:15 CEST in Room “Paris 2”. The symposium will be hosted by Diego Garcia-Borreguero (Spain), Yves Dauvilliers (France), Laura Palagini (Italy), and Christina Lang (Germany), and will explore the latest standard of care for patients with chronic insomnia. Notes to the editor About daridorexantDaridorexant is a dual orexin receptor antagonist (DORA) which blocks the binding of the wake-promoting orexin neuropeptides. Rather than inducing sleep through broad inhibition of brain activity, daridorexant selectively blocks the activation of orexin receptors. Consequently, daridorexant reduces overactive wake signaling, allowing sleep to occur and working throughout the night without altering the proportion of sleep stages. Daridorexant is commercially available as QUVIVIQ in the US, Germany, Italy, Switzerland, Spain, the UK, Canada, Austria, and France, and is approved throughout the EU and in Hong Kong. About IdorsiaIdorsia Ltd is reaching out for more – We have more ideas, we see more opportunities and we want to help more patients. In order to achieve this, we will develop Idorsia into a leading biopharmaceutical company, with a strong scientific core. Headquartered near Basel, Switzerland – a European biotech-hub – Idorsia is specialized in the discovery, development and commercialization of small molecules to transform the horizon of therapeutic options. Idorsia has a 25-year heritage of drug discovery, a broad portfolio of innovative drugs in the pipeline, an experienced team of professionals covering all disciplines from bench to bedside, and commercial operations in Europe and North America – the ideal constellation for bringing innovative medicines to patients. Idorsia was listed on the SIX Swiss Exchange (ticker symbol: IDIA) in June 2017 and has over 750 highly qualified specialists dedicated to realizing our ambitious targets. For further information, please contactAndrew C. WeissSenior Vice President, Head of Investor Relations & Corporate CommunicationsIdorsia Pharmaceuticals Ltd, Hegenheimermattweg 91, CH-4123 Allschwil+41 58 844 10 [email protected]@idorsia.com www.idorsia.com The above information contains certain “forward-looking statements”, relating to the company’s business, which can be identified by the use of forward-looking terminology such as “estimates”, “believes”, “expects”, “may”, “are expected to”, “will”, “will continue”, “should”, “would be”, “seeks”, “pending” or “anticipates” or similar expressions, or by discussions of strategy, plans or intentions. Such statements include descriptions of the company’s investment and research and development programs and anticipated expenditures in connection therewith, descriptions of new products expected to be introduced by the company and anticipated customer demand for such products and products in the company’s existing portfolio. Such statements reflect the current views of the company with respect to future events and are subject to certain risks, uncertainties and assumptions. Many factors could cause the actual results, performance or achievements of the company to be materially different from any future results, performances or achievements that may be expressed or implied by such forward-looking statements. Should one or more of these risks or uncertainties materialize, or should underlying assumptions prove incorrect, actual results may vary materially from those described herein as anticipated, believed, estimated or expected.
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