Can-Fite Receives Notification of Patent Grant from European Patent Office for Namodenoson in the Treatment of NASH

• Marks  Can-Fite’s 3^rd major patent for treatment of NASH; patents have also been received in the U.S. and Korea
• Recently completed Phase II study in NAFLD/NASH achieved primary and secondary endpoints  

PETACH TIKVA, Israel–(BUSINESS WIRE)–Can-Fite BioPharma Ltd. (NYSE American: CANF) (TASE:CFBI), a biotechnology company advancing a pipeline of proprietary small molecule drugs that address inflammatory, cancer and liver diseases, today announced that the European Patent Office has notified the Company of its intent to grant a patent for the invention titled “An A3 Adenosine Receptor For Use In Treating Ectopic Fat Acculturation”. Patent claims include use of the A3 adenosine receptor (A3AR), the target of Can-Fite’s platform technology, in reducing ectopic fat accumulation particularly in fatty liver as manifested in non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH).

“This important patent in Europe comes as Namodenoson exhibited a strong safety profile and met its efficacy endpoints in the treatment of NAFLD and NASH in our recently completed Phase II study. Our global IP portfolio addressing NAFLD/NASH is critical as we engage in talks with potential distribution partners,” stated Can-Fite CEO Dr. Pnina Fishman. “NAFLD and NASH have a very heavy disease burden in Europe, where epidemiology studies estimate the prevalence among the general population of NAFLD at between 29-37%, with 16-45% of those biopsy confirmed as NASH.”

Can-Fite has received patents for Namodenoson in the treatment of NAFLD/NASH in the U.S. and Korea, and the Company has licensing and distribution agreements for Namodenoson in this indication in China and Korea. There is currently no U.S. FDA approved drug for the treatment of NASH, which is an addressable pharmaceutical market estimated to reach $35-40 billion by 2025.

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About Can-Fite BioPharma Ltd.

Can-Fite BioPharma Ltd. (NYSE American: CANF) (TASE: CFBI) is an advanced clinical stage drug development Company with a platform technology that is designed to address multi-billion dollar markets in the treatment of cancer, liver, inflammatory disease and COVID-19. The Company’s lead drug candidate, Piclidenoson, is currently in Phase III trials for rheumatoid arthritis and psoriasis. Can-Fite’s liver drug, Namodenoson, is headed into a Phase III trial for hepatocellular carcinoma (HCC), the most common form of liver cancer, and successfully achieved its primary endpoint in a Phase II trial for the treatment of non-alcoholic steatohepatitis (NASH). Namodenoson has been granted Orphan Drug Designation in the U.S. and Europe and Fast Track Designation as a second line treatment for HCC by the U.S. Food and Drug Administration. Namodenoson has also shown proof of concept to potentially treat other cancers including colon, prostate, and melanoma. CF602, the Company’s third drug candidate, has shown efficacy in the treatment of erectile dysfunction. These drugs have an excellent safety profile with experience in over 1,500 patients in clinical studies to date. For more information please visit: www.can-fite.com.

Forward-Looking Statements

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Contacts

Can-Fite BioPharma

Motti Farbstein

[email protected]
+972-3-9241114