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WaterMill Asset Management Reinforces the Need for Meaningful and Urgent Change at Ziopharm Oncology

Cites Numerous Instances of Ziopharm Continuing to Dismiss Investor Feedback and Disseminate Blatant Distortions, Including Regarding the Company’s Engagement With WaterMill 

Highlights Concerning Interlocks That Still Exist Among Current and Recently-Departed Board Members 

Underscores That Recently-Appointed Directors Mary Thistle and Kevin Buchi Lack Meaningful Ownership Perspectives and Have Presided Over Sizable Share Price Erosion at Other Companies   

Urges Shareholders to Recognize That WaterMill’s Three-Member Slate is the Right Remedy Following Years of Toxic Governance

NEW YORK–(BUSINESS WIRE)–WaterMill Asset Management Corp. (together with its affiliates, “WaterMill” or “we”), which collectively with the other participants in its consent solicitation beneficially owns approximately 3.3% of the outstanding shares of Ziopharm Oncology, Inc. (NASDAQ: ZIOP) (“Ziopharm” or the “Company”), today issued the below letter to shareholders.

As a reminder, WaterMill is encouraging shareholders to consent to all of its proposals by voting on the WHITE consent card. We urge shareholders to sign, date and return their WHITE consent card today. Please return each and every WHITE consent card received. Do not return any green revocation card (even as a protest vote). Learn more at www.FixZiopharm.com.

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December 8, 2020

Fellow Shareholder:

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WaterMill Asset Management Corp. (together with its affiliates, “WaterMill” or “we”) wants to emphasize that Ziopharm Oncology, Inc. (“Ziopharm” or the “Company”) is at a critical inflection point. The Board of Directors (the “Board”) has put Ziopharm on a path to financial ruin by burning through capital, incurring mounting expenses and failing to deliver value-generating clinical progress. Despite receiving blunt investor feedback in recent years, the Board opted to pursue a string of self-directed refreshments that only solidified the Company’s abysmal governance and dismal business practices. This is why we have taken the extraordinary step of initiating a consent solicitation to facilitate meaningful and timely boardroom change.

We firmly believe that our three aligned, independent and well-qualified director candidates collectively represent the right shareholder-driven solution to help Ziopharm quickly reverse its tailspin. Our minority slate possesses the capital allocation acumen, commercial intensity, financial expertise and ownership perspectives that have been lacking in the boardroom for far too long. Each member of our slate also recognizes that Ziopharm’s deteriorating cash position will require a reconstituted Board to expeditiously address challenges and promptly pursue new sources of liquidity.

Although Ziopharm contends that it has tried to engage with WaterMill to settle this contest, these are disingenuous and misrepresentative claims. Not only has the Company taken every opportunity to discredit our integrity-rich director candidates, but all offers to date have been reactive and woefully inadequate relative to the litany of governance issues that exist throughout the c-suite and boardroom. The incumbents’ blatant, last-minute distortions only reinforce why our full slate needs to be added to the Board. Indeed, Ziopharm’s leadership has brazenly dismissed investor input and has refused to even acknowledge that long-term shareholders have had to endure staggering underperformance over every relevant time horizon.

As shareholders consider how to vote in the final days of this consent solicitation process, we believe it is important to focus on an irrefutable fact: Ziopharm’s attempts at incremental and self-directed boardroom change have only fueled more shareholder suffering over the past five years. This is why we have invested considerable energy, resources and time in this campaign to offer shareholders the right solution at the right time. We cannot continue to roll the dice on Ziopharm’s perpetual promises of nearing a so-called turning point that has remained consistently elusive.

DO NOT BE MISLED BY ZIOPHARM’S APPARENT LAST-DITCH EFFORT TO VILIFY WATERMILL AND SMEAR ITS DIRECTOR CANDIDATES

Now that three sizable shareholders and two proxy advisory firms have publicly endorsed WaterMill’s case for change, Ziopharm’s leadership has been scrambling in recent days to demonstrate responsiveness and re-write history. We urge shareholders to take into account the following pieces of context that the incumbents are apparently neglecting to mention in their communications:

“I was chairman of the DemeRx board of directors for a significant portion of Holger’s tenure. He demonstrated integrity, professionalism and the highest degree of ethics at every turn – all in the interest of helping DemeRx succeed. Holger is a by-the-book corporate leader that shuns waste and prioritizes efficiency. In my view, there is no merit to any of the unsubstantiated claims referenced by Ziopharm on November 27.”

We hope that this small sampling of the recent governance failures at Ziopharm reinforces the need for meaningful change in the boardroom. In our view, the Company cannot afford to take half-steps or waste time on another director refresh orchestrated by Mr. Tarriff.

OUR THREE DIRECTOR CANDIDATES ARE THE RIGHT SHAREHOLDER-DRIVEN REMEDY FOLLOWING YEARS OF TOXIC GOVERNANCE AT ZIOPHARM

It is important to stress that WaterMill thought long and hard about the composition of its slate prior to initiating its consent solicitation. After considering Ziopharm’s various needs, we determined that the Board had to be refreshed with aligned and dedicated shareholders who have proven biotechnology experience and financial expertise. A lack of ownership interests in the boardroom has enabled the incumbents to fail at the sole expense of shareholders in recent years.

Fortunately, shareholders can quickly change the composition of the Board and the culture at Ziopharm by voting in the days ahead to elect:

Collectively, our director candidates possess the exact mix of experiences and skills that the Board needs at this juncture. If elected, Messrs. Postma, Vieser and Weis will put this contest behind them and work collegially with their fellow directors to establish a disciplined capital allocation policy, prioritize accretive initiatives and ensure the Company does not run out of capital. WaterMill’s director candidates are equally committed to supporting Dr. Cooper and the management team.

We urge shareholders to assess the sum of the parts of our slate. In our view, we have presented the right solution at the right time.

Sincerely,

WaterMill Asset Management Corp.

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Consent Instructions

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Contacts

For Investors:

Saratoga Proxy Consulting

John Ferguson / Joe Mills, 212-257-1311

jferguson@saratogaproxy.com / jmills@saratogaproxy.com

For Media:

Profile

Greg Marose / Charlotte Kiaie, 347-343-2999

gmarose@profileadvisors.com / ckiaie@profileadvisors.com

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