DUBLIN–(BUSINESS WIRE)–The “Lyophilization Basics for Pharmaceuticals: History, Scientific Principles, Cycles and Formulations” training has been added to ResearchAndMarkets.com’s offering.
This course will act as an introduction to the freeze-drying of pharmaceutical parenteral products.
Many drug substances require the extra protection that lyophilization provides, and the formulation of the liquid drug product must be designed to optimize the efficacy of the finished dried product.
The course will cover how lyophilization works to convert a liquid drug product into a dried, more-stable powder. Cycle and formulation design will be explained, along with the scientific principles that are at play.
Why Should You Attend
To learn the how and why for formulating and designing lyophilization cycles for drugs that will benefit from the freeze-drying process?
Learning Objectives:
- Definition of freeze-drying
- Identify ideal characteristics of a freeze-dried product
- Determine when freeze-drying is necessary
- Phases of the lyo cycle, and the scientific principles that drive each phase
- Formulating drug products for successful freeze-drying
- Analytical tools used to aid in the formulation and cycle development
Agenda
Section 1: History and background
- Definition of freeze-drying, history, and commonly freeze-dried materials
- Desired freeze-dried characteristics
- Advantages and limitations of freeze-drying
- Process overview
Section 2: Physical, chemical, and engineering principles
- Vapour pressure
- Sublimation and the phase diagram of water
- The heat of sublimation of ice
- Rate processes in freeze-drying – heat transfer and mass transfer
- States of matter – crystalline and amorphous
Section 3: Lyo cycle phases
- Freezing (with optional annealing)
- Primary drying (sublimation of water vapour)
- Secondary drying (diffusion and evaporation of water that did not freeze as ice)
Section 4: Lyo formulations
- Excipients for small and large molecules
Section 5: Quality product attributes
- General and specific to freeze-dried products
- Influence of collapse and eutectic melting
For more information about this training visit https://www.researchandmarkets.com/r/tyszsw
Contacts
ResearchAndMarkets.com
Laura Wood, Senior Press Manager
press@researchandmarkets.com
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