DUBLIN–(BUSINESS WIRE)–The “Market
Spotlight: Small-Cell Lung Cancer (SCLC)” report has been added
to ResearchAndMarkets.com’s offering.
This Market Spotlight report covers the small cell lung cancer market,
comprising key pipeline and marketed drugs, recent events and analyst
opinion, probability of success, clinical trials, upcoming and
regulatory events, patent information, a 10-year disease incidence
forecast, licensing and acquisition deals, and drug-specific revenue
forecasts
Key Takeaways
-
The report estimates that in 2017, there were 310,300 incident cases
of small cell lung cancer (SCLC) worldwide, and forecasts that number
to increase to 339,500 incident cases by 2026. -
Northern America is estimated to have the highest disease incidence
(10.43 per 100,000 people), while Africa has the lowest incidence
(0.47 per 100,000 people). -
Celgene’s Amrubicin, Novartis’s Hycamtin (topotecan), Aeterna’s
Lobaplatin, and Bristol-Myers Squibb’s Opdivo (nivolumab) are the only
marketed drugs for SCLC. These drugs are administered via the oral or
intravenous routes. -
The majority of industry-sponsored drugs in active clinical
development for SCLC are in Phase II, with only one drug in the
NDA/BLA phase. -
Therapies in mid-to-late-stage development for SCLC focus on a wide
variety of targets. The majority of the drugs in mid-to-late stage
development are administered via the intravenous route, with the
remainder being oral, intratumoral, intramuscular, or subcutaneous
formulations. -
High-impact upcoming events for drugs in the SCLC space comprise
topline Phase I/II, Phase II/III, and Phase III trial results, and an
FDA decision on an sBLA. -
The overall likelihood of approval of a Phase I solid tumor asset is
5.7%, and the average probability a drug advances from Phase III is
39.4%. Drugs, on average, take 9.5 years from Phase I to approval,
compared to 9.2 years in the overall oncology space. -
There have been 10 licensing and asset acquisition activities
involving SCLC drugs during 2014-19. The license agreement made in
2017 between CytRx and NantCell for the exclusive rights to develop
and market aldoxorubicin for $356m was the largest deal during the
period. -
The distribution of clinical trials across Phase I-IV indicates that
the vast majority of trials for SCLC have been in the early and
mid-phases of development, with 89% of trials in Phase I-II, and only
11% in Phase III-IV. -
The US has a substantial lead in the number of SCLC clinical trials
globally. The UK leads the major EU markets, while Japan has the top
spot in Asia. -
Clinical trial activity in the SCLC space is dominated by completed
trials. GlaxoSmithKline and Pfizer have the highest number of
completed clinical trials for SCLC, with 43 and 41 trials,
respectively. -
Pfizer leads the industry sponsors with the highest number of clinical
trials for SCLC, followed by GlaxoSmithKline.
Key Topics Covered:
OVERVIEW
KEY TAKEAWAYS
DISEASE BACKGROUND
TREATMENT
Chemotherapy
Radiotherapy
Surgery
Palliative procedures
EPIDEMIOLOGY
MARKETED DRUGS
PIPELINE DRUGS
RECENT EVENTS AND ANALYST OPINION
Rova-T for SCLC (December 5, 2018)
Opdivo for SCLC (November 26, 2018)
Trilaciclib for SCLC (November 26, 2018)
Trilaciclib for SCLC (October 21, 2018)
Opdivo for SCLC (October 12, 2018)
Tecentriq for SCLC (September 25, 2018)
Opdivo for SCLC (August 16, 2018)
Tecentriq for SCLC (June 25, 2018)
Rova-T for SCLC (March 22, 2018)
Trilaciclib for SCLC (March 5, 2018)
KEY UPCOMING EVENTS
KEY REGULATORY EVENTS
Tecentriq’s SCLC Success Takes Edge Off Roche’s IO Position
Bristol’s Opdivo Enjoys IO First-Mover Advantage In SCLC
PROBABILITY OF SUCCESS
LICENSING AND ASSET ACQUISITION DEALS
PARENT PATENTS
REVENUE OPPORTUNITY
CLINICAL TRIAL LANDSCAPE
Sponsors by status
Sponsors by phase
Recent events
BIBLIOGRAPHY
Prescription information
APPENDIX
For more information about this report visit https://www.researchandmarkets.com/r/is9n3z
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Related
Topics: Lung
Cancer Drugs