Recruitment for Phase 1/2 CEDAR clinical trial of GPH101 for sickle cell disease underway at multiple sites
Details about CEDAR trial to be presented at 63rd ASH Annual Meeting and Exposition in December
$395.0 million in cash, cash equivalents and restricted cash as of September 30, 2021
SOUTH SAN FRANCISCO, Calif.–(BUSINESS WIRE)–Graphite Bio, Inc. (Nasdaq: GRPH), a clinical-stage, next-generation gene editing company focused on therapies that harness targeted gene integration to treat or cure serious diseases, today reported recent business progress and third quarter 2021 financial results.
“We continue to remain focused on execution as we work to carry out our vision to develop potential one-time cures for patients with a wide range of serious and life-threatening diseases, starting with sickle cell disease,” said Josh Lehrer, M.Phil., M.D., chief executive officer of Graphite Bio. “We were pleased to present preclinical data that are foundational to our sickle cell disease program at the Sickle Cell Disease Association of America’s National Convention last month, and we are excited to share details about our Phase 1/2 CEDAR trial of GPH101 during a poster presentation at the ASH Annual Meeting next month. Importantly, recruitment for our CEDAR trial is underway at multiple clinical trial sites, keeping us on track to enroll our first patient before the end of the year.”
Recent Highlights and Upcoming Milestones
- Activated multiple clinical trial sites for Graphite Bio’s Phase 1/2 CEDAR trial of GPH101, an investigational therapy designed to directly correct the genetic mutation responsible for sickle cell disease (SCD). With patient recruitment and activation of additional clinical trial sites underway, the company remains on track to enroll the first patient in the trial before the end of the year and expects to report initial proof-of-concept data by the end of 2022.
- Received acceptance of an abstract at the 63rd American Society of Hematology (ASH) Annual Meeting and Exposition, which will take place December 11-14 virtually and in Atlanta. Graphite Bio will present details about the company’s Phase 1/2 CEDAR trial of GPH101.
- Presented preclinical data for GPH101 at the 49th Annual SCDAA National Convention. The data presented support the ability of Graphite Bio’s gene editing platform to precisely and efficiently correct the underlying SCD-causing mutation to reduce sickle hemoglobin production and restore adult hemoglobin expression to levels that are considered potentially curative. These data are foundational to the company’s SCD program and support the evaluation of GPH101 in the Phase 1/2 CEDAR trial.
Third Quarter Financial Highlights
- Cash, Cash Equivalents and Restricted Cash: As of September 30, 2021, cash, cash equivalents and restricted cash totaled $395.0 million, which includes approximately $33.2 million in net proceeds received on July 2 from the full exercise of the underwriters’ option to purchase additional shares from the company’s upsized IPO.
- R&D Expenses: Research and development expenses were $8.7 million for the third quarter of 2021, which includes $0.8 million in stock-based compensation expense.
- G&A Expenses: General and administrative expenses were $5.9 million for the third quarter of 2021, which includes $1.6 million in stock-based compensation expense.
- Net Loss: Net loss was $14.6 million, or $0.28 per basic and diluted share, for the three months ended September 30, 2021.
About Sickle Cell Disease (SCD)
SCD is a serious, life-threatening inherited blood disorder that affects approximately 100,000 people in the United States and millions of people around the world, making it the most prevalent monogenic disease worldwide. SCD is caused by a single mutation in the beta-globin gene that leads red blood cells to become misshapen, resulting in anemia, blood flow blockages, intense pain, increased risk of stroke and organ damage, and reduced life span by approximately 20-30 years. Despite advancements in treatment and care, progressive organ damage continues to cause early mortality and severe morbidity, highlighting the need for curative therapies.
About GPH101
GPH101 is an investigational next-generation gene-edited autologous hematopoietic stem cell (HSC) therapy designed to directly correct the genetic mutation that causes sickle cell disease (SCD). GPH101 is the first investigational therapy to use a highly differentiated gene correction approach that seeks to efficiently and precisely correct the mutation in the beta-globin gene to decrease sickle hemoglobin (HbS) production and restore normal adult hemoglobin (HbA) expression, thereby potentially curing SCD.
Graphite Bio is evaluating GPH101 in the CEDAR trial, an open-label, multi-center Phase 1/2 clinical trial designed to assess the safety, engraftment success, gene correction rates, total hemoglobin, as well as other clinical and exploratory endpoints and pharmacodynamics in patients with severe SCD.
About Graphite Bio
Graphite Bio is a clinical-stage, next-generation gene editing company harnessing high efficiency targeted gene integration to develop a new class of therapies to potentially cure a wide range of serious and life-threatening diseases. Graphite Bio is pioneering a precision gene editing approach that could enable a variety of applications to transform human health through its potential to achieve one of medicine’s most elusive goals: to precisely “find & replace” any gene in the genome. Graphite Bio’s platform allows it to precisely correct mutations, replace entire disease-causing genes with normal genes or insert new genes into predetermined, safe locations. The company was co-founded by academic pioneers in the fields of gene editing and gene therapy, including Maria Grazia Roncarolo, M.D. and Matthew Porteus, M.D., Ph.D.
Learn more about Graphite Bio by visiting www.graphitebio.com and following the company on LinkedIn.
Forward-Looking Statements
Statements we make in this press release may include statements which are not historical facts and are considered forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended (the “Securities Act”), and Section 21E of the Securities Exchange Act of 1934, as amended (the “Exchange Act”). These statements may be identified by words such as “aims,” “anticipates,” “believes,” “could,” “estimates,” “expects,” “forecasts,” “goal,” “intends,” “may,” “plans,” “possible,” “potential,” “seeks,” “will,” and variations of these words or similar expressions that are intended to identify forward-looking statements. Any such statements in this press release that are not statements of historical fact, including statements regarding the clinical and therapeutic potential of our gene editing platform and our product candidates, and the timing for enrollment of the first patient in the Phase 1/2 CEDAR trial of GPH101 and the availability of initial proof-of-concept data, may be deemed to be forward-looking statements. We intend these forward-looking statements to be covered by the safe harbor provisions for forward-looking statements contained in Section 27A of the Securities Act and Section 21E of the Exchange Act and are making this statement for purposes of complying with those safe harbor provisions.
Any forward-looking statements in this press release are based on Graphite Bio’s current expectations, estimates and projections only as of the date of this release and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements, including the risk that we may encounter delays in patient enrollment and in the initiation, conduct and completion of our planned clinical trials. These risks concerning Graphite Bio’s programs and operations are described in additional detail in its periodic filings with the U.S. Securities and Exchange Commission, including but not limited to the Company’s most recently filed periodic report. Graphite Bio is providing the information in this press release as of this date and explicitly disclaims any obligation to update any forward-looking statements except to the extent required by law.
|
GRAPHITE BIO, INC. Condensed Statements of Operations (Unaudited) (In thousands, except share and per share data) |
||||||||||||||||||||
|
|
|
|
Three Months Ended |
|
|
|
Nine months ended |
|
||||||||||||
|
|
|
|
September 30, |
|
|
|
September 30, |
|
||||||||||||
|
|
|
|
2021 |
|
|
|
2020 |
|
|
|
2021 |
|
|
|
2020 |
|
||||
|
Operating expenses*: |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and development |
|
$ |
|
8,683 |
|
|
$ |
|
2,310 |
|
|
$ |
|
26,727 |
|
|
$ |
|
2,733 |
|
|
General and administrative |
|
|
|
5,919 |
|
|
|
|
1,454 |
|
|
|
|
14,776 |
|
|
|
|
2,444 |
|
|
Total operating expenses |
|
|
|
14,602 |
|
|
|
|
3,764 |
|
|
|
|
41,503 |
|
|
|
|
5,177 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Loss from operations |
|
|
|
(14,602 |
) |
|
|
|
(3,764 |
) |
|
|
|
(41,503 |
) |
|
|
|
(5,177 |
) |
|
Other income (expense), net: |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Other income (expense), net: |
|
|
|
10 |
|
|
|
|
— |
|
|
|
|
14 |
|
|
|
|
— |
|
|
Change in fair value of the Series A redeemable convertible preferred stock tranche liability |
|
|
|
— |
|
|
|
|
380 |
|
|
|
|
(10,341 |
) |
|
|
|
380 |
|
|
Related party convertible note interest expense |
|
|
|
— |
|
|
|
|
— |
|
|
|
|
— |
|
|
|
|
(40 |
) |
|
Total other income (expense), net |
|
|
|
10 |
|
|
|
|
380 |
|
|
|
|
(10,327 |
) |
|
|
|
340 |
|
|
Net loss and comprehensive loss |
|
$ |
|
(14,592 |
) |
|
$ |
|
(3,384 |
) |
|
$ |
|
(51,830 |
) |
|
$ |
|
(4,837 |
) |
|
Net loss per share attributable to common |
|
$ |
|
(0.28 |
) |
|
$ |
|
(1.00 |
) |
|
$ |
|
(2.51 |
) |
|
$ |
|
(2.53 |
) |
|
Weighted-average shares used in computing net loss
per share attributable to common stockholders – |
|
|
|
52,769,916 |
|
|
|
|
3,382,118 |
|
|
|
|
20,668,560 |
|
|
|
|
1,908,759 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
* Includes stock-based compensation as follows: |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and development |
|
$ |
|
824 |
|
|
$ |
|
6 |
|
|
$ |
|
1,635 |
|
|
$ |
|
6 |
|
|
General and administrative |
|
|
|
1,550 |
|
|
|
|
30 |
|
|
|
|
3,790 |
|
|
|
|
30 |
|
|
Total stock-based compensation expense |
|
$ |
|
2,374 |
|
|
$ |
|
36 |
|
|
$ |
|
5,425 |
|
|
$ |
|
36 |
|
|
GRAPHITE BIO, INC. Condensed Balance Sheets (In thousands) |
||||||||||
|
|
|
September 30, |
|
|
December 31, |
|
||||
|
|
|
2021 |
|
|
2020 |
|
||||
|
|
|
(unaudited) |
|
|
|
|
||||
|
Assets |
|
|
|
|
|
|
|
|
|
|
|
Current assets: |
|
|
|
|
|
|
|
|
|
|
|
Cash and cash equivalents |
|
$ |
|
394,804 |
|
|
$ |
|
19,782 |
|
|
Restricted cash |
|
|
|
149 |
|
|
|
|
35 |
|
|
Prepaid expenses and other current assets |
|
|
|
6,276 |
|
|
|
|
1,286 |
|
|
Total current assets |
|
|
|
401,229 |
|
|
|
|
21,103 |
|
|
Property, plant, and equipment, net |
|
|
|
5,834 |
|
|
|
|
1,461 |
|
|
Operating lease right-of-use assets |
|
|
|
9,077 |
|
|
|
|
— |
|
|
Other assets |
|
|
|
12 |
|
|
|
|
— |
|
|
Total assets |
|
$ |
|
416,152 |
|
|
$ |
|
22,564 |
|
|
Liabilities, redeemable convertible preferred stock, and stockholders’ equity (deficit) |
|
|
|
|
|
|
|
|
|
|
|
Current liabilities: |
|
|
|
|
|
|
|
|
|
|
|
Accounts payable |
|
$ |
|
1,763 |
|
|
$ |
|
630 |
|
|
Accrued compensation |
|
|
|
1,659 |
|
|
|
|
466 |
|
|
Accrued research costs |
|
|
|
1,730 |
|
|
|
|
1,764 |
|
|
Accrued expenses and other current liabilities |
|
|
|
1,314 |
|
|
|
|
126 |
|
|
Current portion of operating lease liabilities |
|
|
|
4,806 |
|
|
|
|
— |
|
|
Series A redeemable convertible preferred stock tranche liability |
|
|
|
— |
|
|
|
|
29,062 |
|
|
Total current liabilities |
|
|
|
11,272 |
|
|
|
|
32,048 |
|
|
Non-current operating lease liabilities |
|
|
|
4,684 |
|
|
|
|
— |
|
|
Other liabilities |
|
|
|
64 |
|
|
|
|
316 |
|
|
Total liabilities |
|
|
|
16,020 |
|
|
|
|
32,364 |
|
|
Series A redeemable convertible preferred stock |
|
|
|
— |
|
|
|
|
55,608 |
|
|
Stockholders’ equity (deficit): |
|
|
|
|
|
|
|
|
|
|
|
Common stock |
|
|
|
1 |
|
|
|
|
— |
|
|
Additional paid-in capital |
|
|
|
522,552 |
|
|
|
|
5,183 |
|
|
Accumulated deficit |
|
|
|
(122,421 |
) |
|
|
|
(70,591 |
) |
|
Total stockholders’ equity (deficit) |
|
|
|
400,132 |
|
|
|
|
(65,408 |
) |
|
Total liabilities, redeemable convertible preferred stock, and stockholders’ equity (deficit) |
|
$ |
|
416,152 |
|
|
$ |
|
22,564 |
|
Contacts
Company:
Stephanie Yao
VP, Communications and Investor Relations
443-739-1423
syao@graphitebio.com
Investors:
Stephanie Ascher
Stern IR, Inc.
212-362-1200
ir@graphitebio.com
Media:
Christy Curran
Sam Brown, Inc.
615-414-8668
media@graphitebio.com