DUBLIN–(BUSINESS WIRE)–The “Market
Spotlight: Celiac Disease” report has been added to ResearchAndMarkets.com’s
offering.
This Market Spotlight report covers the Celiac Disease market,
comprising key pipeline drugs, clinical trials, upcoming events, patent
information, a 10-year disease prevalence forecast, and licensing and
acquisition deals.
Key Takeaways
-
The report estimates that in 2017, there were approximately 89.9
million prevalent cases of celiac disease worldwide, and forecasts
that number to increase to 98.8 million prevalent cases by 2026. -
Prevalence of celiac disease is highest in Europe and Northern
America, and lowest in Africa and Oceania. -
All industry-sponsored drugs in active clinical development for celiac
disease are in Phase I or Phase II. Therapies in development for
celiac disease focus on targets such as gluten, interleukin-15,
interleukin-15 receptor, zonulin and zonulin receptor, immune system,
and T-cell receptor. Pipeline drugs for celiac disease are
administered orally, as well as via the subcutaneous, intradermal, and
intravenous routes. -
High-impact upcoming events for drugs in the celiac disease space
comprise topline Phase III trial results for INN-202. The overall
likelihood of approval of a Phase I autoimmune/immunology asset is
14.5%, and the average probability a drug advances from Phase III is
68%. Drugs, on average, take 8.7 years from Phase I to approval in the
overall autoimmune/immunology space -
There have been five licensing and asset acquisition deals involving
celiac disease drugs during 2014-19. The largest deal during the
period was the $170m licensing and co-development agreement signed in
2018 between Amgen and Provention Bio, for the development of
anti-IL-15 antibody AMG 714 for the treatment of gluten-free diet
non-responsive celiac disease. -
The distribution of clinical trials across Phase I-III indicates that
the vast majority of trials for celiac disease have been in the mid
and late phases of development, with 91% of trials in Phase II-III,
and only 9% in Phase I. -
The US has a substantial lead in the number of celiac disease clinical
trials globally. Innovate Biopharmaceuticals has the highest number of
completed trials for celiac disease, with six trials, and also leads
industry sponsors with the highest number of clinical trials for
celiac disease overall.
Key Topics Covered:
OVERVIEW
KEY TAKEAWAYS
DISEASE BACKGROUND
Subtypes
TREATMENT
EPIDEMIOLOGY
PIPELINE DRUGS
KEY UPCOMING EVENTS
PROBABILITY OF SUCCESS
LICENSING AND ASSET ACQUISITION DEALS
Amgen Links With Provention For AMG 714 In Celiac Disease
PARENT PATENTS
CLINICAL TRIAL LANDSCAPE
Sponsors by status
Sponsors by phase
BIBLIOGRAPHY
APPENDIX
For more information about this report visit https://www.researchandmarkets.com/r/tdhx2v
Contacts
ResearchAndMarkets.com
Laura Wood, Senior Press Manager
press@researchandmarkets.com
For
E.S.T. Office Hours Call 1-917-300-0470
For U.S./CAN Toll Free Call
1-800-526-8630
For GMT Office Hours Call +353-1-416-8900
Related
Topics: Immune
Disorders Drugs, Gastrointestinal
Drugs